Gelatin sponge containing prednisolone acetate relieves radicular pain following posterior lumbar interbody fusion

doi:10.3969/j.issn.2095-4344.2016.30.011

Abstract

Abstract:

BACKGROUND: Posterior lumbar interbody fusion can thoroughly decompress the central canal, which is the common surgical technique for the central type of lumbar disc herniation with intervertebral instability at low lumbar segment. However, due to the regular traction on dural sac and nerve root in the operation, lower limb radicular pain in the early stage is inevitable.
OBJECTIVE: To evaluate the effect of local use of gelatin sponge containing prednisolone acetate around the nerve roots after posterior lumbar interbody fusion on lower limb radicular pain.
METHED: Sixty-three cases of lumbar disc herniation with degenerative instability were devided into treatment group (n=21) and control group (n=42) based on the type of implants. Gelatin sponge containing prednisolone acetate was implanted into patients in the treatment group after posterior lumbar interbody fusion, while pure gelatin sponge was implanted into patients in the control group.
RESULTS AND CONCLUSION: Compared with the control group, radicular pain in the treatment group was significantly relieved within 1 week after surgery. The visual analog scale score and Oswestry disability index score were similar between the two groups. There were three cases of radicular pain recurrence in the control group, but no incision infection and epidural hematoma after surgery in both two groups. In conclusion, local use of gelatin sponge containing prednisolone acetate around the nerve roots can significantly relieve lower limb radicular pain in the early stage after posterior lumbar interbody fusion in lumbar disc herniation, contributing to early rehabilitation exercise and patient satisfaction outcomes.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Prednisolone, Intervertebral Disk Displacement, Spinal Fusion, Tissue Engineering

CLC Number:

R318

Yao Zhen-song, Chen Kang, Jiang Xiao-bing, Liang De, Tang Jing-jing. Gelatin sponge containing prednisolone acetate relieves radicular pain following posterior lumbar interbody fusion[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(30): 4483-4488.

Figures/Tables 6

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